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As discussed earlier, regulation of expression of GCK is different in cells and hepatocytes.
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Because type 2 diabetes is primarily managed in the primary care setting and not by endocrinologists, the study was designed to recruit patients from primary care practices.
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The glucose alanine cycle, like the Cori cycle, shifts part of the metabolic burden from extrahepatic tissues to the liver.
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Notice that the enzyme, like many proteins that act outside of cells, is covered with carbohydrate chains, shown in green.