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Once Phosphorylated, Pgc1 Translocates From The Cytosol To The Nucleus, The Place It Promotes The Transcription Of Genes Involved In Fatty Acid Transport, Fat Oxidation, And Oxidative Phosphorylation Pgc1 Could Probably Be Phosphorylated By Way Of A Number Of Totally Different Pathways, Amongst Them Ampk, Calcium Calmodulin Dependent Protein Kinase, And P38 Mitogen Activated Protein Kinase Pathways Pgc1 Can Be Activated By A Sirt1 Mediated Deacetylation Ampk Can Exert Its Motion Each Via Phosphorylation Of Pgc1 Or In A Direct Method At The Same Time, Ampk Activation Additionally Inhibits Mtor Signalling However, It Appears Counterintuitive To Inhibit An Essential Growth Mediated Pathway Ie, Mtor , Regulating Muscle Mass, So That .
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