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2 Deoxy D glucose 2 DG, 4, 8, or 16 mM significantly reduces the level of ATP in MCF 7 cells in a dose and time dependent manner that paralleles the effects of 2 DG on cell growth.
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Experiments in b and c were performed twice, and that in d 3 times.
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Autophagy can be activated upon metabolic stress eg starvation of cells, as well as upon other stressors including hypoxia and inflammation, to promote cellular survival under these conditions.
Notice that the enzyme, like many proteins that act outside of cells, is covered with carbohydrate chains, shown in green.
Data obtained in human newborn infants suggest that hepatic ketone synthesis is restricted during the early neonatal period.