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Costa hungry and high blood sugar et al pointed out that G6PD mutants causing class 1 variants cluster within exon 10, in a region that, at the protein level, is believed to be involved in dimerization.
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The mutation underlying the A variant is the most ancient and the mutation underlying the A variant is the most recent.
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G6PD and HPRT are linked in the Chinese hamster and presumably are on the X chromosome as in man.
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